Yesterday, I learned from Tsinghua University that the research group of Professor Yan Ning of the school medical school first analyzed the crystal structure of the human glucose transporter GLUT1, which will block the “nutrition chain†of cancer cells and hope to “starve†cancer. cell. This achievement has been published in the British magazine Nature, which was officially published the day before, and has been well received by the industry.
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According to reports, glucose is the most important and basic source of energy for various organisms on the planet. The first step in glucose metabolism is to enter the cell, the most basic unit of the human body, but water-soluble glucose cannot pass through a hydrophobic cell membrane like oil. Therefore, the role of the transporter as a "transportation machine" that traverses cell membranes is extremely important.
Yan Ning said that GLUT1 also plays an important role in the metabolism of cancer cells. Cancer cells need to consume excess glucose to maintain their growth and expansion, and a significant excess of GLUT1 in the cells often means canceration. Therefore, if we can study the composition, structure and working mechanism of GLUT1, it is possible to achieve artificial intervention of glucose transport by regulating it, which can increase the supply of glucose in normal cells to achieve the purpose of treating diseases, and can also block cancer cells by blocking The supply of glucose thus "starved" cancer cells.
