Mechanism of action of antibacterial veterinary drugs

Antibacterial veterinary drugs can selectively inhibit the life function of pathogens without affecting the physiological and biochemical functions of animals such as livestock and poultry. Therefore, in the process of using antibacterial veterinary drugs to prevent pathogen infection, it is necessary to consider between antibacterial veterinary drugs, pathogenic bacteria and animals. Interrelationship. The main mechanism of action of antibacterial veterinary drugs can be summarized into five kinds: 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

1. Inhibit and interfere with the synthesis of bacterial cell walls. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

There is a tough cell wall outside the bacterial cell membrane to maintain the shape and osmotic pressure of the bacteria, while the animal cells have no cell wall. The use of antibacterial veterinary drugs such as penicillin can damage and destroy bacterial cell walls without affecting animal cells. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

2. Damage to the cell membrane of bacteria. Some bacterial and mold cell membranes are more susceptible to drug damage than animal cell membranes. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

Drugs such as polymyxin and nystatin can damage the bacterial cell membrane, causing leakage of cells and causing death. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

3. Affect the synthesis of proteins in bacterial cells. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

Different antibacterial veterinary drugs can cause different results. Antibacterial veterinary drugs such as chloramphenicol, erythromycin and tetracycline can act on different stages of protein synthesis, inhibit the synthesis of bacterial proteins, stop breeding but not die, and are bacteriostatic. Antibacterial veterinary drugs; after the removal of antibacterial drugs, it can restore protein synthesis, re-growth and reproduction. Streptomycin, kanamycin and the like can quickly kill pathogenic bacteria and are bactericidal antibacterial veterinary drugs. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

4. Inhibit the synthesis of bacterial nucleic acids and hinder the replication of genetic information. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

5. Competitive inhibition and interference with the intermediate metabolism of bacteria. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry

Some of the chemical substances in antibacterial veterinary drugs have a structure similar to that required for the growth of bacteria. During the growth process, bacteria may mistakenly use certain components of the antibacterial veterinary drug as substances necessary for their own growth, thereby hindering The metabolism of bacteria. Sulfonamides inhibit growth and reproduction by inhibiting bacterial folate metabolism. 7aZ China Feed Industry Information Network - based on feed, serving animal husbandry